Human TM7SF3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TM7SF3
Locus ID	51768
Kit Components	GA109985G1, TM7SF3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109985G2, TM7SF3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109985G3, TM7SF3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_016551
Synonyms	2010003B14Rik; NARP1; OTTMUSP00000031284; transmembrane 7 superfamily member 3
Summary	Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).[UniProtKB/Swiss-Prot Function]

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