Human SLC22A17 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SLC22A17
Locus ID	51310
Kit Components	GA109729G1, SLC22A17 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109729G2, SLC22A17 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109729G3, SLC22A17 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001289050, NM_016609, NM_020372, NR_110290
Synonyms	24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3
Summary	Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).[UniProtKB/Swiss-Prot Function]

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