Human SPG3A (ATL1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ATL1
Locus ID	51062
Kit Components	GA109529G1, SPG3A gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109529G2, SPG3A gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109529G3, SPG3A gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001127713, NM_015915, NM_181598
Synonyms	AD-FSP; atlastin1; FSP1; GBP3; HSN1D; SPG3; SPG3A
Summary	The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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