Human TPRKB activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TPRKB
Locus ID	51002
Kit Components	GA109487G1, TPRKB gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109487G2, TPRKB gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109487G3, TPRKB gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001330386, NM_001330387, NM_001330388, NM_001330389, NM_001330390, NM_001330391, NM_001330392, NM_016058
Synonyms	CGI-121; CGI121
Summary	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828).[UniProtKB/Swiss-Prot Function]

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