Human EMR2 (ADGRE2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ADGRE2
Locus ID	30817
Kit Components	GA109387G1, EMR2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109387G2, EMR2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109387G3, EMR2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001271052, NM_013447, NM_152916, NM_152917, NM_152918, NM_152919, NM_152920, NM_152921
Synonyms	CD312; EMR2
Summary	This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

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