Human WDR91 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	WDR91
Locus ID	29062
Kit Components	GA109206G1, WDR91 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109206G2, WDR91 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109206G3, WDR91 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_014149, NM_001362737, NM_001362738, NR_156131, NM_001362736, NR_156130
Synonyms	HSPC049; SORF-1; SORF1
Summary	Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB/Swiss-Prot Function]

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