Human NKIRAS2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NKIRAS2
Locus ID	28511
Kit Components	GA109159G1, NKIRAS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109159G2, NKIRAS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109159G3, NKIRAS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001001349, NM_001144927, NM_001144928, NM_001144929, NM_017595
Synonyms	kappaB-Ras2; KBRAS2
Summary	Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).[UniProtKB/Swiss-Prot Function]

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