Human Bcl2 Binding component 3 (BBC3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	BBC3
Locus ID	27113
Kit Components	GA109015G1, Bcl2 Binding component 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109015G2, Bcl2 Binding component 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109015G3, Bcl2 Binding component 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001127240, NM_001127241, NM_001127242, NM_014417
Synonyms	JFY-1; JFY1; PUMA
Summary	This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

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