Human GAPex 5 (GAPVD1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GAPVD1
Locus ID	26130
Kit Components	GA108765G1, GAPex 5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108765G2, GAPex 5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108765G3, GAPex 5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001282679, NM_001282680, NM_001282681, NM_001330777, NM_001330778, NM_015635, NM_001354293, NM_001354294, NM_001354295, NM_001354296, NM_001354297, NM_001354298, NM_001354299, NM_001354300, NM_001354301, NR_148732, NR_148733
Synonyms	GAPex-5; GAPEX5; RAP6
Summary	Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.[UniProtKB/Swiss-Prot Function]

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