Human VIRMA activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	VIRMA
Locus ID	25962
Kit Components	GA108661G1, VIRMA gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108661G2, VIRMA gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108661G3, VIRMA gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_015496, NM_183009
Synonyms	fSAP121; MSTP054
Summary	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3' UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3' UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755).[UniProtKB/Swiss-Prot Function]

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