Human POT1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	POT1
Locus ID	25913
Kit Components	GA108626G1, POT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108626G2, POT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108626G3, POT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001042594, NM_015450, NR_003102, NR_003103, NR_003104
Synonyms	CMM10; GLM9; HPOT1
Summary	This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

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