Human SLC39A14 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SLC39A14
Locus ID	23516
Kit Components	GA108360G1, SLC39A14 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108360G2, SLC39A14 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108360G3, SLC39A14 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001128431, NM_001135153, NM_001135154, NM_015359, NM_001351655, NM_001351656, NM_001351657, NM_001351658, NM_001351659, NM_001351660
Synonyms	cig19; HMNDYT2; LZT-Hs4; NET34; ZIP14
Summary	This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]

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