Human PHF15 (JADE2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	JADE2
Locus ID	23338
Kit Components	GA108231G1, PHF15 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108231G2, PHF15 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108231G3, PHF15 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001289984, NM_001289985, NM_001308143, NM_015288
Synonyms	JADE-2; PHF15
Summary	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo (PubMed:16387653). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity).[UniProtKB/Swiss-Prot Function]

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