Human EST1A (SMG6) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SMG6
Locus ID	23293
Kit Components	GA108195G1, EST1A gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108195G2, EST1A gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108195G3, EST1A gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001170957, NM_001256827, NM_001256828, NM_001282326, NM_017575, NR_046385
Synonyms	C17orf31; EST1A; KIAA0732; SMG-6
Summary	This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]

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