Human SNX13 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SNX13
Locus ID	23161
Kit Components	GA108083G1, SNX13 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108083G2, SNX13 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108083G3, SNX13 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_015132, NM_001350862, NM_001350863, NM_001350864, NM_001350865, NM_001350866, NM_001350867, NM_001350868, NM_001350870, NR_146933, NR_146932
Synonyms	RGS-PX1
Summary	This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]

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