Human Neurofascin (NFASC) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NFASC
Locus ID	23114
Kit Components	GA108048G1, Neurofascin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108048G2, Neurofascin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108048G3, Neurofascin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001005387, NM_001005388, NM_001005389, NM_001160331, NM_001160332, NM_001160333, NM_015090, NM_001365986
Synonyms	DKFZp686P2250; FLJ46866; KIAA0756; NF; NRCAML
Summary	This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

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