Human GRAF (ARHGAP26) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ARHGAP26
Locus ID	23092
Kit Components	GA108031G1, GRAF gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108031G2, GRAF gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108031G3, GRAF gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001135608, NM_015071, NM_001349547, NR_146198
Synonyms	GRAF; GRAF1; OPHN1L; OPHN1L1
Summary	Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

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