Human ZC3H13 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZC3H13
Locus ID	23091
Kit Components	GA108030G1, ZC3H13 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108030G2, ZC3H13 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108030G3, ZC3H13 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001076788, NM_001330564, NM_001330565, NM_001330566, NM_001330567, NM_015070
Synonyms	KIAA0853
Summary	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3' UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity).[UniProtKB/Swiss-Prot Function]

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