Human HECW1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HECW1
Locus ID	23072
Kit Components	GA108016G1, HECW1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108016G2, HECW1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108016G3, HECW1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001287059, NM_015052
Synonyms	NEDL1
Summary	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.[UniProtKB/Swiss-Prot Function]

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