Human TCP1 epsilon (CCT5) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CCT5
Locus ID	22948
Kit Components	GA107932G1, TCP1 epsilon gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107932G2, TCP1 epsilon gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107932G3, TCP1 epsilon gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001306153, NM_001306154, NM_001306155, NM_001306156, NM_012073
Synonyms	CCT-epsilon; CCTE; HEL-S-69; PNAS-102; TCP-1-epsilon
Summary	The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]

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