Human RIPX (RUFY3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RUFY3
Locus ID	22902
Kit Components	GA107897G1, RIPX gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107897G2, RIPX gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107897G3, RIPX gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001037442, NM_001130709, NM_001291993, NM_001291994, NM_001345840, NM_014961
Synonyms	RIPX; SINGAR1; ZFYVE30
Summary	This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

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