Human CARD8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CARD8
Locus ID	22900
Kit Components	GA107895G1, CARD8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107895G2, CARD8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107895G3, CARD8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001184900, NM_001184901, NM_001184902, NM_001184903, NM_001184904, NM_014959, NR_033678, NR_033679, NR_033680, NM_001351782, NM_001351783, NM_001351784, NM_001351786, NM_001351787, NM_001351788, NM_001351789, NM_001351790, NM_001351791, NM_001351792, NR_147707, NM_001365950
Synonyms	CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN
Summary	The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

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