Human TFEC activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TFEC
Locus ID	22797
Kit Components	GA107817G1, TFEC gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107817G2, TFEC gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107817G3, TFEC gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001018058, NM_001244583, NM_012252
Synonyms	bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L; TFECL
Summary	This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

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