Human KLHL2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	KLHL2
Locus ID	11275
Kit Components	GA107770G1, KLHL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107770G2, KLHL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107770G3, KLHL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001161521, NM_001161522, NM_007246, NM_001331023, NM_001331024
Synonyms	ABP-KELCH; MAV; MAYVEN
Summary	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.[UniProtKB/Swiss-Prot Function]

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