Human AP4S1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	AP4S1
Locus ID	11154
Kit Components	GA107676G1, AP4S1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107676G2, AP4S1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107676G3, AP4S1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001128126, NM_001254726, NM_001254727, NM_001254728, NM_001254729, NM_007077
Synonyms	AP47B; CLA20; CLAPS4; CPSQ6; SPG52
Summary	This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Mutations in this gene are associated with spastic quadriplegic cerebral palsy-6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Dec 2011]

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