Human DBF4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DBF4
Locus ID	10926
Kit Components	GA107493G1, DBF4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107493G2, DBF4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107493G3, DBF4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001318060, NM_001318061, NM_001318062, NM_006716
Synonyms	ASK; CHIF; DBF4A; ZDBF1
Summary	Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.[UniProtKB/Swiss-Prot Function]

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