Human Influenza Virus NS1A Binding Protein (IVNS1ABP) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IVNS1ABP
Locus ID	10625
Kit Components	GA107276G1, Influenza Virus NS1A Binding Protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107276G2, Influenza Virus NS1A Binding Protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107276G3, Influenza Virus NS1A Binding Protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_006469, NM_016389
Synonyms	FLARA3; HSPC068; KLHL39; ND1; NS-1; NS1-BP; NS1BP
Summary	Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).[UniProtKB/Swiss-Prot Function]

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