Human MAD4 (MXD4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MXD4
Locus ID	10608
Kit Components	GA107261G1, MAD4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107261G2, MAD4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107261G3, MAD4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_006454
Synonyms	bHLHc12; MAD4; MST149; MSTP149
Summary	This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]

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