Human SH2B2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SH2B2
Locus ID	10603
Kit Components	GA107257G1, SH2B2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107257G2, SH2B2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107257G3, SH2B2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_020979, NM_001359228, NM_001359229, NM_001359230, NM_001359231
Synonyms	APS
Summary	The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

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