Human SPTLC1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SPTLC1
Locus ID	10558
Kit Components	GA107218G1, SPTLC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107218G2, SPTLC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107218G3, SPTLC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001281303, NM_006415, NM_178324, NM_001368273, NM_001368272
Synonyms	HSAN1; HSN1; LBC1; LCB1; SPT1; SPTI
Summary	This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013]

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