Human FBXW10 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	FBXW10
Locus ID	10517
Kit Components	GA107183G1, FBXW10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107183G2, FBXW10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107183G3, FBXW10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001267585, NM_001267586, NM_031456, NR_051988
Synonyms	Fbw10; HREP; SM2SH2; SM25H2
Summary	Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

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