Human Apc10 (ANAPC10) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ANAPC10
Locus ID	10393
Kit Components	GA107081G1, Apc10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107081G2, Apc10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107081G3, Apc10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001256706, NM_001256707, NM_001256708, NM_001256709, NM_001256710, NM_001256711, NM_001256712, NM_001318367, NM_014885, NR_046345
Synonyms	APC10; DOC1
Summary	ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

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