Human SRRM1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SRRM1
Locus ID	10250
Kit Components	GA106978G1, SRRM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106978G2, SRRM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106978G3, SRRM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001303448, NM_001303449, NM_005839, NM_001366577, NM_001366589, NM_001366600, NM_001366566, NM_001366567, NM_001366569, NM_001366570, NM_001366572, NM_001366575, NM_001366576, NM_001366581, NM_001366582, NM_001366585, NM_001366587, NM_001366590, NM_001366592, NM_001366594, NM_001366595, NM_001366596, NM_001366597, NM_001366599, NR_159379, NR_159382, NR_159383, NR_159384, NR_159385, NR_159386, NR_159387, NR_159388, NR_159389, NR_159391, NM_001366565, NM_001366568, NM_001366571, NM_001366573, NM_001366578, NM_001366584, NM_001366586, NM_001366588, NM_001366591, NM_001366593, NM_001366598, NR_159378, NR_159380, NR_159390
Synonyms	160-KD; POP101; SRM160
Summary	Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.[UniProtKB/Swiss-Prot Function]

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