Human CTDSPL activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CTDSPL
Locus ID	10217
Kit Components	GA106947G1, CTDSPL gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106947G2, CTDSPL gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106947G3, CTDSPL gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001008392, NM_005808
Synonyms	C3orf8; HYA22; PSR1; RBSP3; SCP3
Summary	Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.[UniProtKB/Swiss-Prot Function]

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