Human RASGRP1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RASGRP1
Locus ID	10125
Kit Components	GA106869G1, RASGRP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106869G2, RASGRP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106869G3, RASGRP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001128602, NM_001306086, NM_005739
Synonyms	CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; V
Summary	This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

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