Human CTDSP2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CTDSP2
Locus ID	10106
Kit Components	GA106855G1, CTDSP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106855G2, CTDSP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106855G3, CTDSP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_005730
Synonyms	OS4; PSR2; SCP2
Summary	Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.[UniProtKB/Swiss-Prot Function]

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