Human DRP1 (DNM1L) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DNM1L
Locus ID	10059
Kit Components	GA106816G1, DRP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106816G2, DRP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106816G3, DRP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001278463, NM_001278464, NM_001278465, NM_001278466, NM_001330380, NM_005690, NM_012062, NM_012063
Synonyms	DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV
Summary	This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

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