Human FLASH (CASP8AP2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CASP8AP2
Locus ID	9994
Kit Components	GA106767G1, FLASH gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106767G2, FLASH gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106767G3, FLASH gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001137667, NM_001137668, NM_012115
Synonyms	CED-4; FLASH; RIP25
Summary	This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]

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