Human DLEC1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DLEC1
Locus ID	9940
Kit Components	GA106723G1, DLEC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106723G2, DLEC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106723G3, DLEC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_005106, NM_007335, NM_007336, NM_007337, NM_007338, NM_001321153
Synonyms	deleted in lung and esophageal cancer 1; deleted in lung cancer 1; DLC1; F56; F56, DLC1
Summary	The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]

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