Human RABGAP1L activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RABGAP1L
Locus ID	9910
Kit Components	GA106696G1, RABGAP1L gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106696G2, RABGAP1L gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106696G3, RABGAP1L gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001035230, NM_001243763, NM_001243764, NM_001243765, NM_014857, NM_001330989, NM_001366445, NM_001366447, NM_001366448, NM_001366451, NM_001366452, NM_001366453, NM_001366457, NR_158982, NM_001366446, NM_001366449, NM_001366450, NM_001366454, NM_001366455, NM_001366456, NR_158981
Synonyms	HHL; TBC1D18
Summary	GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).[UniProtKB/Swiss-Prot Function]

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