Human SMG7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SMG7
Locus ID	9887
Kit Components	GA106675G1, SMG7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106675G2, SMG7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106675G3, SMG7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001174061, NM_014837, NM_173156, NM_201568, NM_201569, NM_001331007, NM_001350219, NM_001350220, NM_001350221, NM_001350222
Synonyms	C1orf16; EST1C; SGA56M
Summary	This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

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