Human RAPGEF5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RAPGEF5
Locus ID	9771
Kit Components	GA106575G1, RAPGEF5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106575G2, RAPGEF5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106575G3, RAPGEF5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_012294, NM_001367600, NM_001367602, NM_001367601, NM_001367603
Synonyms	GFR; MR-GEF; REPAC
Summary	Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

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