Human KIAA0100 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	KIAA0100
Locus ID	9703
Kit Components	GA106514G1, KIAA0100 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106514G2, KIAA0100 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106514G3, KIAA0100 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001321560, NM_001321561, NM_014680, NM_001363827, NM_001363828, NM_001363829, NM_001363826
Synonyms	BCOX; BCOX1; CT101; FMP27
Summary	This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain. [provided by RefSeq, Apr 2017]

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