Human RNF14 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RNF14
Locus ID	9604
Kit Components	GA106430G1, RNF14 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106430G2, RNF14 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106430G3, RNF14 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001201365, NM_004290, NM_183398, NM_183399, NM_183400, NM_183401
Synonyms	ARA54; HFB30; HRIHFB2038; TRIAD2
Summary	The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

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