Human Otoferlin (OTOF) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	OTOF
Locus ID	9381
Kit Components	GA106261G1, Otoferlin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106261G2, Otoferlin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106261G3, Otoferlin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001287489, NM_004802, NM_194248, NM_194322, NM_194323
Synonyms	AUNB1; DFNB6; DFNB9; FER1L2; NSRD9
Summary	Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has 3 C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has 6 C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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