Human LONP1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LONP1
Locus ID	9361
Kit Components	GA106242G1, LONP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106242G2, LONP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106242G3, LONP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001276479, NM_001276480, NM_004793, NR_076392
Synonyms	CODASS; hLON; LON; LonHS; LONP; PIM1; PRSS15
Summary	This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]

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