Human LGI1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LGI1
Locus ID	9211
Kit Components	GA106141G1, LGI1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106141G2, LGI1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106141G3, LGI1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001308275, NM_001308276, NM_005097, NR_131777
Synonyms	ADLTE; ADPAEF; ADPEAF; EPITEMPIN; EPT; ETL1; IB1099
Summary	This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

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