Human USP6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	USP6
Locus ID	9098
Kit Components	GA106057G1, USP6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106057G2, USP6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106057G3, USP6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001039674, NM_001304284, NM_004505, NM_005152
Synonyms	HRP1; Tre-2; TRE2; TRE17
Summary	Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.[UniProtKB/Swiss-Prot Function]

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