Human WAVE 1 (WASF1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	WASF1
Locus ID	8936
Kit Components	GA105956G1, WAVE 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105956G2, WAVE 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105956G3, WAVE 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001024934, NM_001024935, NM_001024936, NM_003931
Synonyms	SCAR1; WAVE; WAVE1
Summary	The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

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