Human HM74 (HCAR3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HCAR3
Locus ID	8843
Kit Components	GA105885G1, HM74 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105885G2, HM74 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105885G3, HM74 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_006018
Synonyms	GPR109B; HCA3; HM74; Puma-g; PUMAG
Summary	Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.[UniProtKB/Swiss-Prot Function]

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